Oh, Fun: Perimenopause Might Be Making Your Migraine Attacks Worse

Here’s why it’s happening—and how to deal.
Why Perimenopause Migraine Attacks Happen and How to Treat Them
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If you’re in perimenopause—a transition phase that signals menopause is around the corner—you may have started to notice some big body changes going down: hot flashes, vaginal dryness, lower libido, mood swings, and disrupted sleep, to name a (frustrating) few common symptoms. They’re happening because your hormones are in flux, causing your body to release eggs (or ovulate) less frequently and have more irregular periods.

This stage of life—which occurs anywhere between your mid-30s to your late 50s, or right up until whenever you hit menopause—is understandably stressful, and if you’ve been experiencing head pain to boot, you might attribute it to the emotional roller coaster of it all. But as is the case with most perimenopause woes, worsening migraine symptoms could be a result of those shifting hormones: A report from The Journal of Head and Face Pain found that a person in perimenopause is 62% more likely than a premenopausal individual to have high-frequency headaches, which was defined as more than 10 days with a headache each month.1 (For reference, premenopausal people have, on average, four or fewer.)

While many folks with migraine are diagnosed in their teens or 20s, roughly 8 to 13% don’t get diagnosed until they’re in perimenopause because their symptoms—including headaches, nausea, and fatigue—become much more intense.2

“Wide fluctuations in estrogen levels occur during perimenopause, which may be a key driver of increased migraine frequency,” William Renthal, MD, PhD, neurologist and director of headache research at the John R. Graham Headache Center at Brigham and Women’s Hospital, tells SELF. In addition to prevalence, Dr. Renthal notes that a lot of his perimenopausal patients also say their migraine headaches get more severe and often shift from one side of the head to the other (or even centers near the eyes). Many of them also report an uptick in symptoms unrelated to the headache itself, like nausea and vomiting.

Here’s why your head pain might be surging in perimenopause—and what you can do about it.

Why changing hormones can intensify migraine symptoms

According to Dr. Renthal, doctors aren’t entirely sure why hormonal shifts during perimenopause impact migraine frequency and severity. However, research does show a connection between estrogen withdrawal and migraine.3 (Meaning: The less estrogen you’re pumping out, the higher your likelihood of getting intense headaches.) Other studies, largely done in rats, suggest that changes in estrogen make certain cells more excitable—which may make you more sensitive to migraine triggers.4

Estrogen also controls a bunch of neurotransmitters in the brain, so when you have less of it, you’re a lot more susceptible to pain. Fluctuating estrogen can also increase a person’s mast cells, a type of immune cell that triggers inflammation in the brain and often increases headache pain, Dr. Renthal says.

Brain chemistry aside, all the physical and emotional shifts that can happen during perimenopause—like mood changes, sleep disturbances, hot flashes, and night sweats—may exacerbate attacks, Addie Peretz, MD, a neurologist and clinical assistant professor of neurology and neurological sciences at Stanford Medicine, tells SELF.

Both experts agree that more studies are needed in order to better understand estrogen’s role in it all. “Such research could reveal new ways to treat menstrual migraine, as well as perimenopausal migraine,” Dr. Renthal says.

How to relieve migraine pain during perimenopause

You can’t avoid perimenopause, but there are things you can do to make the migraine attacks associated with this phase of life a lot more manageable.

An initial step (and perhaps one you’ve heard before) is to address lifestyle factors that can trigger or worsen migraine symptoms during perimenopause, including poor sleep, not eating regularly, a lack of exercise, dehydration, smoking, and drinking alcohol, Dr. Renthal says. Alternative treatments like breathing exercises, relaxation techniques, and massage can also help alleviate attacks if stress is a major trigger for you. Biofeedback training—a mind-body technique that helps people spot indicators that an attack is near, like tensing muscles or rapid breathing—has also been shown to help. (A primary care doctor can usually refer you to someone—like a nurse, psychologist, or physical therapist—trained in the alternative-medicine method .)

Certain prescription migraine medications can help prevent attacks, including anti-epileptics, beta-blockers, tricyclic antidepressants, and monoclonal calcitonin gene-related peptide (CGRP) antibodies.2 And nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, as well as triptans can sometimes ease head pain when an attack is already in motion.5

Hormone replacement therapy, which restores some of the estrogen you lose in perimenopause and menopause, may also improve migraine symptoms in some people, Dr. Peretz adds. But your doctor can ultimately help you decide if it’s right for you: “For others, it can trigger worsened migraine attacks or new onset neurologic symptoms,” she says.

What treatment method does the trick will boil down to individual factors, like how intense and persistent your headaches are, other medications you’re taking, potential side effects you experience, and how much money you’re able to pay out of pocket. It starts with listening to your body and finding a supportive care team so that the next time perimenopause sends your hormones—and perhaps your head—spinning, you’ve got a plan to lean on for relief.


  1. The Journal of Head and Face Pain, Perimenopause and Menopause Are Associated With High-Frequency Headache in Women With Migraine: Results of the American Migraine Prevalence and Prevention Study
  2. Women’s Midlife Health, The Impact of Midlife on Migraine in Women: Summary of Current Views
  3. Systematic Reviews, The Complex Relationship Between Estrogen and Migraines: A Scoping Review
  4. Frontiers in Molecular Biosciences, TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain
  5. Journal of Clinical Medicine, Acute and Preventive Management of Migraine During Menstruation and Menopause


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